Pracownicy służby zdrowia


Limitations in how we
currently measure success for
patients with Fabry disease

A range of assessments and schedules are recommended to monitor different organ systems in adult patients with Fabry disease.1 However, there has been no systematic way to evaluate the frequency and impact of signs and symptoms, or to identify which are the most debilitating and most important in terms of quality of life (QoL).2

Current recommendations include: 

  • Laboratory measurements, including Gb3 levels, lyso-Gb3 levels, albuminuria test and eGFR.1  Additional monitoring dictated by each patients individual clinical course3 

  • Multisystemic monitoring – all relevant systems must be assessed, treated and monitored individually4 


Can patient-reported outcomes offer a different perspective? 

Patient reported outcomes may be measured with: 

  • SF-36 questionnaire: assesses 8 domains of QoL - Physical Functioning, Role Physical, Bodily Pain, General Health, Vitality/Energy, Social Functioning, Role Emotional, and Mental5 

  • EQ-5D questionnaire: assesses 5 domains of QoL - mobility, self-care, usual activities, pain, and anxiety/depression5 

Postęp choroby Fabry’ego i wyniki zgłaszane przez pacjentów

Better understanding of QoL in different disease states and improved understanding of the influence of specific symptoms and complications on QoL may facilitate targeted treatment, and improve the well-being of Fabry patients.6 


eGFR, estimated glomerular filtration rate; Gb3, globotriaosylceramide; lyso-Gb3, globotriaosylsphingosine; SF-36, 36-Item Short Form Health Survey.

Improving multidisciplinary care for patients, now and in the future

Clinical evaluations should involve a multidisciplinary team of subspecialists, which should be coordinated by a physician experienced in the care of patients with Fabry disease.3

A care team may include physicians of the following specialties:1

    Choroba Fabry’ego a kardiologia


    Choroba Fabry’ego a nefrologia


    Neurologia w chorobie Fabry’ego


    Psychologia w chorobie Fabry’ego


    Genetyka w chorobie Fabry’ego


    Podstawowa opieka zdrowotna w chorobie Fabry’ego

    Primary care

If you or your patients don’t have access to all of the specialists noted above, directing your patients to the following resources may help them learn more about their condition:


    European Society of Cardiology


    European Kidney Patients Federation


    European Federation of Neurological Associations


    European Foundation for Psychologists and Analysts


    Patients Network for Medical Research and Health


    The Voice of Rare Disease Patients in Europe

Helping your patients navigate their care team

Supportive care is important.7 To help your patients understand the importance of a multidisciplinary approach, consider advising them that:

Therapeutic management of Fabry disease requires a multidisciplinary approach by medical specialists experienced in treating this rare condition.4

Comprehensive monitoring regardless of age, sex, or treatment status, should be conducted at regular intervals.4

Annual evaluations ensure that they receive optimal interventions and support.3

Results from each specialist will come together to form a complete picture of their health.1

Working with specialists early will allow for the collection of baseline measurements, which can help the team see signs of progression early.1

Zespół specjalistów w leczeniu choroby Fabry’ego

It’s important for them to work with a multidisciplinary care team, even if they are not currently experiencing symptoms in a given part of their body.1,5

Their family members with Fabry may experience the disease in a distinct way.2

Introducing Chiesi Global Rare Diseases

At Chiesi Global Rare Diseases, we’re working to build a brighter future for patients.

We want to revolutionize the lives of patients living with rare diseases by providing an integrated set of definitive solutions.8

The patients are the beginning and the end of our journey. For them, we work in close partnership with patients, caregivers, patient associations, healthcare practitioners, and regulatory and pricing authorities.8

We strive to build a brighter future for the patients we serve; we relentlessly pursue sustainable growth with passion, courage, teamwork, and innovation.8

We are fully committed to rethinking what is possible in Fabry disease. Together, we can take action to make a change.


  1. Ortiz A, et al. Mol Genet Metab. 2018;123(4):416-427.
  2. Hamed A, et al. Orphanet J Rare Dis. 2021;16:285.
  3. Desnick RJ, et al. Ann Intern Med. 2003;138(4):338-346.
  4. Eng CM, et al. Genet Med. 2006;8(9):539-548.
  5. Arends M, et al. Orphanet J Rare Dis. 2015;10(77):1-10.
  6. Arends M, et al. J Inherit Metab Dis. 2018;41(1):141-149.
  7. Germain DP. Fabry disease. Orphanet J Rare Dis. 2010;5:30.
  8. Chiesi Global Rare Diseases Institutional Presentation, June 2021.

Chiesi w sieci

Dla pacjentów - W razie konieczności zgłoszenia niepożądanego działania leku, należy się zwrócić się do lekarza, prosząc go o wypełnienie i przedłożenie opisu przypadku do odpowiedniej instytucji ds. zdrowia, zgodnie z wymogami nadzoru nad bezpieczeństwem farmakoterapii obowiązującymi w Państwa kraju. Przypominamy również, że każdy pacjent może zgłaszać takie przypadki bezpośrednio do krajowego systemu raportowania.


Dla pracowników służby zdrowia: w razie konieczności zgłoszenia niepożądanego działania leku, należy się zwrócić do odpowiedniej instytucji ds. zdrowia, zgodnie z wymogami nadzoru nad bezpieczeństwem farmakoterapii obowiązującymi w danym kraju.


Opuszczasz stronę Rethink Fabry. Uwaga: strona, na którą wchodzisz, nie jest własnością firmy Chiesi ani nie jest przez nią zarządzana